Enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones using a novel N,N,P–Cu(II) complex |
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| Authors: | Yasuhiro Ebisu Kenjiro Kawamura Masahiko Hayashi |
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| Institution: | Department of Chemistry, Graduate School of Science, Kobe University, Nada, Kobe 657-8501, Japan |
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| Abstract: | Enantioselective copper-catalyzed 1,4-additions of dialkylzincs to enones were carried out in the presence of 1 mol % of Cu(OTf)2 and 2.5 mol % of an N,N,P-ligand possessing a tert-butyl group at the adjacent position of the nitrogen of pyridine to afford the corresponding 1,4-adducts in up to 98% ee. |
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