Rh(I)-catalyzed asymmetric addition of arylboronic acids to NH isatins |
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| Authors: | Jiangyang Gui Guihua Chen Peng Cao Jian Liao |
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| Institution: | 1. Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China;2. Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China;3. Graduate School of Chinese Academy of Sciences, Beijing 100049, PR China |
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| Abstract: | The transition metal-catalyzed asymmetric variant of the title reaction is normally limited to N-protected isatins. However, Rh(I)/chiral sulfoxide phosphine complexes were found to catalyze the enantioselective addition of arylboronic acids to NH isatins under mild conditions. A variety of chiral 3-aryl-3-hydroxyl-2-oxindoles were obtained with high yields and with good to excellent enantioselectivities (85–92% ee). |
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