Asymmetric total synthesis of 5′-epi-paecilomycin-F |
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Authors: | Nandan Jana Samik Nanda |
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Institution: | Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India |
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Abstract: | The asymmetric total synthesis of one of the stereoisomers of the naturally occurring 14-membered ring macrolide paecilomycin-F (5′-epi) has been reported in this article. The main highlight of the synthetic strategy involves the successful application of a ring closing metathesis (RCM) reaction at a late stage. Asymmetric Keck allylation, Sharpless asymmetric dihydroxylation, and Mitsunobu esterification have also been used successfully for the total synthesis of 5′-epi-paecilomycin-F. |
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