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Efficient kinetic resolution of amino acids catalyzed by lipase AS ‘Amano’ via cleavage of an amide bond |
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| Authors: | Bo Wang Yanfeng Liu Dela Zhang Yuhong Feng Jiacheng Li |
| Institution: | 1. Key Laboratory of Tropical Biological Resources of Ministry of Education, Haikou 570228, Hainan University, PR China;2. KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Center, SE-106 91 Stockholm, Sweden |
| Abstract: | Herein the efficient kinetic resolution of non-natural alpha-amino acids catalyzed by lipase AS ‘Amano’ via cleaving the amide bond is reported. The starting materials were the corresponding amino acid amides and the amino acids were generated with ees of up to 99% with E values of >600. These results indicated that the lipase AS ‘Amano’ could be a powerful amide hydrolase for the kinetic resolution of amino acid starting from the corresponding amino acid amides. |
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