A new chemoenzymatic approach to the synthesis of chiral 4-aryl-1,4-dihydro-2H-isoquinolines via the enzymatic resolution of 2-acetyl-4-phenyl-1,4-dihydro-2H-isoquinolin-3-one |
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Authors: | Dominik Koszelewski Malgorzata Cwiklak Ryszard Ostaszewski |
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Affiliation: | 1. Institute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland;2. Industrial Chemistry Research Institute, Rydygiera 8, 01-793 Warsaw, Poland |
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Abstract: | A new chemoenzymatic method is proposed for the synthesis of enantiomerically pure 4-phenyl-1,4-dihydro-2H-isoquinolines based on the enzymatic kinetic resolution of 2-acetyl-4-phenyl-1,4-dihydro-2H-isoquinolin-3-one. For the enzymatic resolution of the racemic substrate, readily available ‘home made’ animal liver acetone powders (LAPs) were used. Excellent enantioselectivity, exceeding 500, was achieved in a short reaction time upon application of turkey liver acetone powder as the biocatalyst. Reduction of obtained product led to the formation of amine (R)-1, which is hardly available using standard procedures. These results show that N-acetyl lactams are a new type of substrate for enzymatic biotransformations. |
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