Double axially chiral bisphosphorylimides as novel Brønsted acids in asymmetric three-component Mannich reaction |
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| Authors: | Ying-Ying Chen Yi-Jun Jiang Yan-Sen Fan Di Sha Qifeng Wang Guangliang Zhang Liangyu Zheng Suoqin Zhang |
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| Institution: | 1. College of Chemistry, Jilin University, Changchun 130012, PR China;2. Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130012, PR China |
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| Abstract: | A double axially chiral bisphosphorylimide has been demonstrated to be an efficient and highly sterically hindered Brønsted acid in asymmetric three-component Mannich reactions. Optically active syn-β-amino ketones were obtained in high yields (up to 99%) with excellent diastereoselectivity (99:1) and enantioselectivity (up to 99% ee). A gram-scale reaction was also performed to prove the synthetic application value of this reaction. |
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