Chiral Diels–Alder reaction between cyclopentadiene and nitroso derivatives: thermal isomerisation/racemisation of the adducts |
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Authors: | Jean-Marc Heuchel Sébastien Albrecht Christiane Strehler Albert Defoin Céline Tarnus |
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Institution: | Laboratoire de Chimie Organique et Bioorganique, EA4466, Université de Haute-Alsace, ENSCMu, 3 rue Alfred Werner, F-68093 Mulhouse Cedex, France |
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Abstract: | Cyclopentadiene nitroso adducts 1a and ent-1a were synthesised in good yields and good enantiomeric excess from chiral chloro-nitroso derivatives 4 and 5 in the d-mannose and d-ribose series, respectively. The thermal racemisation of these adducts occurred below room temperature. Some other chiral Diels–Alder nitroso adducts were prepared in the d-mandelic, l-prolinol and d-O-methylprolinol series and their thermal isomerisation was specified according to the N-substitution. A simple synthesis of the chiral amido-cyclopentenol (+)-2b, an important precursor for biological interesting compounds, is presented from ent-1a. |
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