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Intramolecular Huisgen [3+2] cycloaddition in water: synthesis of fused pyrrolidine–triazoles |
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| Authors: | Indresh Kumar Nisar A Mir Chandrashaker V Rode Basant P Wakhloo |
| Institution: | 1. School of Biology & Chemistry, College of Sciences, Shri Mata Vaishno Devi University, Katra 182 320, J&K, India;2. Chemical Engineering & Process Development Division, National Chemical Laboratory, Pune 411 008, India;3. Instrumentation Division, Indian Institute of Integrative Medicine (IIIM-CSIR Lab.), Canal Road, Jammu 180 001, J&K, India |
| Abstract: | The intramolecular alkyne–azide Huisgen 3+2] cycloaddition reaction as a ‘click-chemistry’ reaction without a metal catalyst has been studied under aerobic conditions. The synthesis of various pyrrolidine–triazole hybrid compounds has also been achieved by using this intramolecular cycloaddition reaction in water with complete 1,5-regioselectivity. |
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