In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum |
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| Authors: | Raja Mohamed Beema Shafreen Selvaraj Alagu Lakshmi Shunmugiah Karutha Pandian Young-Mo Kim Joseph Deutsch Elena Katrich Shela Gorinstein |
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| Institution: | 1.Department of Biotechnology, Dr. Umayal Ramanathan College for Women, Algappapuram, Karaikudi 630003, India;2.Department of Biotechnology, Alagappa University, Science Campus, Karaikudi 630003, India; (S.A.L.); (S.K.P.);3.Industry Academic Collaboration Foundation, Kwangju Women’s University, Gwangju 62396, Korea;4.Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel; (J.D.); (E.K.) |
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| Abstract: | Previous reports have shown that consumption of wine has several health benefits; however, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candidates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications. |
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| Keywords: | beverages health properties antioxidant activities fibrinogen albumin rutin tannic acid resveratrol binding properties |
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