A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine |
| |
| Authors: | Peng Zhi-Hui Journet Michel Humphrey Guy |
| |
| Institution: | Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. zhihui_peng@merck.com |
| |
| Abstract: | reaction: see text]. A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine with aliphatic secondary amines and aromatic amines has been developed which strongly favors the formation of the C4-substituted product. The reactions with aliphatic amines are carried out using LiHMDS as the base and are catalyzed by Pd, while the aromatic amines require no catalyst. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
