| 9-羟基-9-呫吨羧酸甲酯和中间体的合成 |
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| 引用本文： | 孔博,弓亚玲,胡文祥.9-羟基-9-呫吨羧酸甲酯和中间体的合成[J].化学通报,2009,72(6). |
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| 作者姓名： | 孔博 弓亚玲 胡文祥 |
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| 作者单位： | 首都师范大学化学系,北京,100048
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| 摘 要： | 9-羟基-9-咕吨羧酸甲酯是合成咕吨类抗胆碱能药物的一种重要的中间体.本文以9-咕吨羧酸为原料,通过微波催化先合成了中间体9-咕吨羧酸甲酯,然后很简便地得到了9-羟基-9-咕吨羧酸甲酯.在中间体的合成中,利用正交设计,探讨了微波辐射时间、功率以及催化剂用量对反应的影响,实验结果表明微波辐射时间的影响最为显著.
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| 关 键 词： | 9-羟基-9-咕吨羧酸甲酯 9-咕吨羧酸甲酯 微波催化 正交设计 |
Synthesis of Methyl 9-Hydroxyl-9-xanthene Carboxyate and Intermediate |
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| Kong Bo,Gong Yaling,Hu Wenxiang.Synthesis of Methyl 9-Hydroxyl-9-xanthene Carboxyate and Intermediate[J].Chemistry,2009,72(6). |
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| Authors: | Kong Bo Gong Yaling Hu Wenxiang |
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| Institution: | Department of Chemistry;Capital Normal University;Beijing 100048 |
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| Abstract: | Methyl 9-hydroxyl-9-xanthene carboxyate which is an important intermediate of xanthene anticholiergic drugs was easily synthesized from methyl 9-xanthene carboxyate. Synthesis of methyl 9-xanthene carboxyate by microwave catalysis was studied through orthogonal design,the effect of time and power of microwave and amount of catalyst were investigated. It was found that the effect of time was notable. |
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| Keywords: | Methyl 9-hydroxyl-9-xanthene carboxyate Methyl 9-xanthene carboxyate Microwave catalysis Orthogonal design |
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