A new total synthesis of the zinc matrixmetalloproteinase inhibitor ageladine A featuring a biogenetically patterned 6pi-2-azatriene electrocyclization |
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| Authors: | Meketa Matthew L Weinreb Steven M |
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| Affiliation: | Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. |
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| Abstract: | [reaction: see text] A convergent second generation total synthesis of the heterocyclic marine sponge metabolite ageladine A has been achieved by using a biomimetically inspired 6pi-2-azatriene electrocyclization as the key step for formation of the imidazolopyridine moiety. |
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