Synthesis of 2-amino-6-(nitroimidazolyl)thiopurines |
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| Authors: | P. M. Kochergin E. V. Aleksandrova V. S. Korsunskii V. S. Shlikhunova |
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| Affiliation: | (1) Drug Chemistry Center, All-Russian Pharmaceutical Chemistry Scientific Research Institute, 119815 Moscow;(2) Zaporozhe State Medical University, 330074 Zaporozhe, Ukraine |
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| Abstract: | We have synthesized a series of novel 2-amino-6-(nitroimidazolyl)thiopurines by reaction of thioguanine with 1-alkyl(1,2-dialkyl)-5-chloro-4-nitro-, 2-alkyl(1,2-dialkyl)-5-bromo-4-nitro-, and 1-alkyl(1,2-dialkyl)-4-chloro-5-nitroimidazoles.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 221–224, February, 2000. |
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| Keywords: | halonitroimidazoles nitroimidazolylthioguanines thioguanine immunodepressants |
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