Alkaloids of Aconitum coreanum. X. Curare-Like Activity-Structure Relationship |
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| Authors: | F. N. Dzhakhangirov I. A. Bessonova |
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| Affiliation: | (1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent |
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| Abstract: | The biological activity of 11 alkaloids isolated from Aconitum coreanum was studied. The compounds exhibit myorelaxant activity. Isoatisine and coryphine, which contain oxazolidine rings, are the most active. N-Oxides of 2-isobutyryl-14-hydroxyhetisine and 2-isobutyryl-13-acetyl-14-hydroxyhetisine are least active. |
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| Keywords: | Aconitum coreanum Ranunculaceae diterpenoid alkaloids toxicity curare-like activity |
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