Alkalimetric determination of hydrophobic pharmaceuticals using stabilized o/w emulsions |
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| Authors: | Ganna M Shevchenko Sergey A Kulichenko |
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| Institution: | (1) Analytical Chemistry Department, Faculty of Chemistry, Taras Shevchenko Kyiv University, Volodymyrska Str. 64, Kyiv, 01033, Ukraine |
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| Abstract: | Protolytic properties of (+)-(S)-2-(6-methoxynaphthalen-2-yl)propanoic acid (naproxen), 2-(3-benzoylphenyl)propionic acid (ketoprofen), 4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid (furosemide), and N-(2,3-dimethylphenyl)anthranilic acid (mefenamic acid) in “oil-in-water” emulsions stabilized by surfactants were studied.
The procedures for alkalimetric determination of naproxen, ketoprofen, furosemide, and mefenamic acid in emulsion media with
indication of the equivalence point pH-metrically and with the use of indicators were proposed. |
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| Keywords: | pK protolytic properties hydrophobic pharmaceuticals emulsion media alkalimetric determination |
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