Inhibitory effect of TNF-alpha and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum |
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| Authors: | Cai Xing Fu Shen Guanghai Dat Nguyen Tien Kang Ok Hwa Kim Jin A Lee Young Mi Lee Jung Joon Kim Young Ho |
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| Institution: | College of Pharmacy, Chungnam National University, Daejeon, Korea. |
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| Abstract: | A new pimarane-type diterpene compound, acanthokoreoic acid A together with three known compounds, acanthoic acid, acanthol, and sumogaside were isolated from a CH(2)Cl(2) fraction of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. Acanthoic acid was isolated in high yields and showed potent inhibitory activity on the IL-8 secretion of the TNF-alpha-stimulated human colon adenocarcinoma cell line HT-29 and on the TNF-alpha secretion of the trypsin-stimulated human leukemic mast cell line HMC-1. |
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