Partition coefficients of ketones,phenols, aliphatic and aromatic acids,and esters in n-hexane/nitromethane

Liquid-liquid partition is used in sample preparation and in countercurrent and liquid-liquid chromatographic separations. Partition coefficients are widely used in toxicology, environmental, and analytical chemistry. The K _hn determination procedure for the n-hexane/nitromethane system was optimized and partition coefficients for 99 ketones, esters and trimethylsilyl derivatives of phenols, aliphatic and aromatic acids were determined. For 130 compounds, K _hn values were predicted using mathematical relationships between K _hn and other physicochemical and structural parameters.