HPLC-assisted automated oligosaccharide synthesis |
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| Authors: | Ganesh N Vijaya Fujikawa Kohki Tan Yih Horng Stine Keith J Demchenko Alexei V |
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| Institution: | Department of Chemistry and Biochemistry and the Center for Nanoscience, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. |
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| Abstract: | A standard HPLC was adapted to polymer supported oligosaccharide synthesis. Solution-based reagents are delivered using a software-controlled solvent delivery system. The reaction progress and completion can be monitored in real time using a standard UV detector. All steps of oligosaccharide assembly including loading, glycosylation, deprotection, and cleavage can be performed using this setup. |
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