Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative |
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| Authors: | Samanta Subhas Qin Chuanguang Lough Alan J Woolley G Andrew |
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| Affiliation: | Dept. of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada. |
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| Abstract: | It goes both ways: A thiol-reactive cross-linker based on a bridged azobenzene derivative permits photoreversible control of peptide conformation on irradiation with violet (407?nm) and green (500-550?nm) light (see picture) through isomerization of the cross-linker. The large separation of the absorbance bands of the cis (yellow) and trans (red) isomers enables complete bidirectional photoswitching. |
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| Keywords: | azo compounds helical structures peptides photocontrol photoisomerization |
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