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Ag(I) ion mediated formation of a C-A mispair by DNA polymerases |
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| Authors: | Funai Tatsuya Miyazaki Yuki Aotani Megumi Yamaguchi Eriko Nakagawa Osamu Wada Shun-ichi Torigoe Hidetaka Ono Akira Urata Hidehito |
| Affiliation: | Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. |
| Abstract: | Silver turns up the A-C: In the presence of Ag(I) ions, a DNA polymerase incorporated deoxyadenosine (from dATP) at the site opposite cytosine in the template strand to afford the full-length product (see scheme), meaning that DNA polymerases prefer a C-Ag(I)-A base pair to the more thermodynamically stable C-Ag(I)-C base pair. |
| Keywords: | DNA polymerases DNA recognition metal ion‐mediated base pairs primer extension silver ions |
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