Tandem bis-aldol reaction of ketones: a facile one-pot synthesis of 1,3-dioxanes in aqueous medium |
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| Authors: | Polshettiwar Vivek Varma Rajender S |
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| Affiliation: | Sustainable Technology Division, National Risk Management Research Laboratory, U. S. Environmental Protection Agency, Cincinnati, OH 45268, USA. |
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| Abstract: | A novel tandem bis-aldol reaction of ketone with paraformaldehyde catalyzed by polystyrenesulfonic acid in aqueous medium delivers 1,3-dioxanes in high yield. This one-pot, operationally simple microwave-assisted synthetic protocol proceeds efficiently in water in the absence of organic solvent, with excellent yield. |
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