Structural confirmation of regioisomers of Lopinavir impurities using MS and gradient COSY (1H and 13C NMR assignment of Lopinavir impurities) |
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Authors: | Siva Lakshmi Devi A Srinivasa Rao Y Suresh Y Yogeswar Reddy M Jyothi G Rajababu B Prasad V S R Umamaheswar Rao V |
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Institution: | Analytical Research and Development, Matrix Laboratories Ltd., Jeedimetla, Hyderabad, India. sivalakshmi@matrixlabsindia.com |
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Abstract: | We report the complete (1)H and (13)C NMR assignment of impurities of six Lopinavir (2S)-N-(2S, 4S, 5S)-5-{2-(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenyl hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butan- amide. Two of the impurities are regioisomers and GCOSY used to differentiate the two structures. The spectral assignments for all six impurities were achieved by concerted application of one and two-dimensional NMR techniques ((1)H NMR, (13)C NMR, DEPT, GCOSY, GHSQC and GHMBC). |
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Keywords: | 1H NMR 13C NMR DEPT GCOSY GHSQC GHMBC Lopinavir regioisomers Lopinavir impurities |
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