支气管哮喘患者吸入白细胞介素-5所致细胞间粘附因子增高的研究

采用随机、双盲及设置对照组的办法进行研究。在吸入ＩＬ５之前，对８例不吸烟的哮喘患者及６例非哮喘过敏性疾病患者测定其痰及血清的ｓＩＣＡＭ１；吸入ＩＬ５后，于２ｈ、２４ｈ、４８ｈ及７２ｈ取上述标本分别测定其ｓＩＣＡＭ１的水平。结果示对照组患者的ｓＩＣＡＭ１在整个研究过程中都没有明显的改变。但吸入ＩＬ５后支气管哮喘患者于痰中ｓＩＣＡＭ１出现明显的增高，于４８ｈ达最高峰，但持续不超过７２ｈ。同样的结果亦出现在血清中。研究表明ＩＬ５可能是导致支气管哮喘患者痰及血的ｓＩＣＡＭ１增高的原因，对非哮喘过敏疾病患者则无此作用。

Increased Concentrations of Soluble Intracellular Adhesion Molecule-1 in Bronchial Asthmatics Caused by Inhaled Interleukin-5

In a randomized double blind, placebo controlled study design, eight nonsmoking patients with allergic asthma and six non asthmatic allergic subjects were administered recombinant human interleukin (IL) 5 by nebulization, and the concentrations of soluble (s) ICAM 1 in both induced sputum and serum from each subject were determined before and at 2, 24, 48, 72 h after inhalation, respectively. Our results showed that sICAM 1 levels neither in sputum nor serum within the control group had no change from baseline at any time throughout the study. In allergic asthmatics, vehicle challenge was not able to cause any changes in sICAM 1 levels in both sputum and serum. However, there was an increase in sputum sICAM 1 levels after IL 5 inhalation, which increased with time was significantly greater than baseline value, respectively, reaching a maximum at 48 h, and lasted no more than 72 h.And a similar elevation in serum sICAM 1 levels after IL 5 inhalation was observed in asthmatics. Our results indicated that IL 5 was capable of inducing elevations of both sputum and serum sICAM 1 concentrations in allergic asthmatics, but not in non asthmatic allergic subjects.