硫酸特布他林在聚铬黑T修饰电极上的电化学行为及其测定

采用电化学聚合法制备了聚铬黑T膜修饰电极，应用扫描电镜、交流阻抗法和循环伏安法对修饰电极进行表征，以循环伏安法研究硫酸特布他林在修饰电极上的电化学行为，并以差示脉冲伏安法对其含量进行测定.该方法对硫酸特布他林有明显的电催化作用，在pH 7.0磷酸盐缓冲液中，氧化峰电流与硫酸特布他林浓度在1.2x10^-7~2.0x10^-6mol•L^-1范围内呈良好的线性关系，检测限为1.5x10^-8 mol•L^-1，回收率在97.9%～104.6%之间，RSD在2.8 % (C=8x10^-7mol•L^-1，n=11).该方法简便灵敏，结果准确可靠，方法重复性好，可用于硫酸特布他林及其片剂的质量控制.

Electrochemical Behaviors and Determinations of Terbutaline Sulfate at Poly Eriochrome Black T Modified Electrode

The poly eriochrome black T modified electrode was prepared by electropolymerization. This modified electrode was characterized by scanning electron microscopy(SEM), electrochemical impedance spectroscopy(EIS) and cyclic voltammetry (CV). The electrochemical behaviors of terbutaline sulfate were studied by CV, while the recoveries were measured by differential pulse voltammetry (DPV). The modified electrode shows excellent electrocatalytic characteristics for terbutaline sulfate. In pH 7.0 phosphate buffer solution, the oxidation peak currents obtained by DPV were linear to the terbutaline sulfate concentrations over the range of1.2x10^-7~2.0x10^-6mol•L^-1. The detection limit was estimated to be1.5x10^-8mol•L^-1 and the average recovery was 97.9%～104.6%. The relative standard deviation (RSD) was 2.8% for8x10^-7mol•L^-1terbutaline sulfate (n=11). This method is simple, sensitive, and accurate with good repeatability, and can be used for the determination of terbutaline sulfate and the corresponding tablets.