Some N-substituted 2-amino- and 2-methylquinoline-3,4-dicarboximides

The reaction of sodium 2-amino-3-cyanoquinoline-4-carboxylate and 2-methyl-3-cyanoquino-line-4-carboxylic acid in polyphosphoric acid led to 2-amino- and 2-methylquinoline-3,4-dicar-boximide, respectively. Both of these compounds undergo imide N-alkylation reactions with methyl iodide and various chloroalkylaminodialkyl amines, while the latter also condenses with 3,4-dichlorobenzaldehyde to form styryl derivatives. Although some of these compounds may be considered structural analogs of the antimalarial 4-quinolinemethanols, none exhibited antimalarial activity.