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A facile and rapid synthesis of N-benzyl-2-substituted piperazines |
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| Authors: | Mouhamad Jida Mohamad Soueidan Nicolas Willand Francine Agbossou-Niedercorn Lydie Pelinski Guillaume Laconde Rebecca Deprez-Poulain Benoit Deprez |
| Affiliation: | a INSERM U761 Biostructures and Drug Discovery, Lille F-59000, France b Faculté de Pharmacie, Université Lille Nord de France, Lille F-59000, France c Institut Pasteur de Lille, IFR 142, Lille F-59021, France d PRIM, Lille F-59000, France e UMR CNRS 8181 Unité de Catalyse et de Chimie du Solide, Université Lille, Cité Scientifique Villeneuve d′Ascq F-59655, France |
| Abstract: | A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80-92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry. |
| Keywords: | Multicomponent reaction UGI Piperazines Microwave |
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