Pd-catalyzed and CsF-promoted reaction of bromoalkynes with isocyanides: regioselective synthesis of substituted 5-iminopyrrolones |
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| Authors: | Li Yibiao Zhao Jian Chen Huoji Liu Bifu Jiang Huanfeng |
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| Affiliation: | School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China. |
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| Abstract: | The palladium-catalyzed and CsF-promoted annulation reaction of bromoalkynes and isocyanides regioselectively affords a diverse set of 5-iminopyrrolone derivatives. This chemistry presumably proceeds through the bromoacrylamide intermediates, which can be readily prepared from the nucleophilic addition reaction of isocyanides to bromoalkynes in the presence of CsF. |
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