Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide |
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| Authors: | Allan Phoebe K Wheatley Paul S Aldous David Mohideen M Infas Tang Chiu Hriljac Joseph A Megson Ian L Chapman Karena W De Weireld Guy Vaesen Sebastian Morris Russell E |
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| Institution: | School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, Scotland, UK. |
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| Abstract: | Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis. |
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