Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives |
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| Authors: | Xin Guo Yi Liang Li Yu Fei Liud Hui Yuan Guoa Yu Cheng Wang a Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences Peking Union Medical College Beijing China b College of Pharmaceutical Sciences Southwest University Chongqing China c Tianjin Institute of Pharmaceutical Research Tianjin Key Laboratory of Molecular Design & Drug Discovery Tianjin China d Xuzhou Medical College Xuzhou China |
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| Institution: | a Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;b College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;c Tianjin Institute of Pharmaceutical Research, Tianjin Key Laboratory of Molecular Design & Drug Discovery, Tianjin 300193, China;d Xuzhou Medical College, Xuzhou 221004, China |
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| Abstract: | A series of novel 7-(3-aminopyrrolo3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives were designed, synthesized and evaluated for in vitro antibacterial activities. Compounds 6g, 7g and 7h with the potencies similar to those of gemifloxacin, moxifloxacin, gatifloxacin and levofloxacin against Gram-positive organisms, worth further investigation. |
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| Keywords: | Fluoroquinolone Synthesis Antibacterial activities |
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