Palladium-catalyzed intramolecular O-arylation of enolates: application to benzo[b]furan synthesis |
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| Authors: | Willis Michael C Taylor Dawn Gillmore Adam T |
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| Affiliation: | Department of Chemistry, University of Bath, Bath BA2 7AY, UK. m.c.willis@bath.ac.uk |
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| Abstract: | [reaction: see text] A catalyst generated from Pd2(dba)3 and the ligand DPEphos effects intramolecular C-O bond formation between enolates and aryl halides in the conversion of 1-(2-haloaryl)ketones directly into the corresponding benzofurans. Both cyclic and acyclic ketones are efficient substrates. Thio ketones can also be employed allowing the preparation of the corresponding benzothiophenes. |
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