Quantitative Determination of Adrenaline Hydrochloride Injection and Noradrenaline Bitartrate Injection by a New HPLC Method via Substitute for Reference Substance |
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| Authors: | XIE Yuan-chao HUANG Hai-wei ZHANG Qi-ming JIN Shao-hong |
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| Affiliation: | [1]Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, P. R. China [2]Shandong Provincial Institute for Drug Control, Jinan 250101, P. R. China [3]National Institute for Control of Pharmaceutical and Biological Products, Beijing 100050, P. R. China |
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| Abstract: | An HPLC method for quantitative determination of adrenaline hydrochloride injection and noradrenaline bitartrate injection was established and validated with a substitute for the reference substance.Phenylephrine hydrochloride was selected as the substitute for the reference substance of adrenaline and noradrenaline bitartrate.The correction factor of phenylephrine hydrochloride with respect to the reference substance of adrenaline and noradrenaline bitartrate was determined under defined conditions.Adrenal... |
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| Keywords: | Substitute for reference substance Correction factor Adrenaline Noradrenaline bitartrate Phenylephrine hydrochloride HPLC |
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