Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides |
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| Authors: | Jones Mathew W Strickland Rachel A Schumacher Felix F Caddick Stephen Baker James R Gibson Matthew I Haddleton David M |
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| Institution: | Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL. |
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| Abstract: | The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation. |
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