A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines |
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| Authors: | Chen Jie Zhou Ling Yeung Ying-Yeung |
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| Institution: | Department of Chemistry, National University of Singapore, Singapore. |
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| Abstract: | A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine. |
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