Microwave-assisted Suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites |
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Authors: | Sharma Arun K Gowdahalli Krishnegowda Krzeminski Jacek Amin Shantu |
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Affiliation: | Department of Pharmacology, Chemical Carcinogenesis and Chemoprevention Program of Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA. aks14@psu.edu |
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Abstract: | A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to approximately 24 h under thermal conditions, corresponding to a approximately 72-fold increase in reaction rate. |
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