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Imaging Therapeutic Proteins in Gelatin for Controlled Drug Release |
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| Authors: | Amy Wagoner Johnson Nilda Juan Serrano Abby Whittington Morgan Russell Jamison Young Bin Choy Hyungsoo Choi Kyekyoon (Kevin) Kim Francesco DeCarlo |
| Affiliation: | 1. Department of Mechanical and Industrial Engineering, University of Illinois at Urbana-Champaign, 1206 W. Green St., Urbana, IL, 61801, USA;2. Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green St., Urbana, IL, 61801, USA;3. Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 W. Green St., Urbana, IL, 61801, USA;4. Advanced Photon Source, Argonne National Laboratory, 9700 Cass Ave., Argonne, IL, 60439, USA |
| Abstract: | Preliminary results from this study show that x-ray microcomputed tomography can be used to image model proteins for bone inducing growth factors. Small quantities (<1 μg protein/mg gelatin) of soybean trypsin inhibitor labeled with either gold nanoparticles or nonradioactive iodine were detected using synchrotron radiation. These results could lead to a new method of measuring the release profile of therapeutic proteins. |
| Keywords: | confocal microscopy drug delivery systems protein tomography x-ray imaging |