Relative retention analysis in HPLC: The correlation between incremental relationships

It was shown that, in the absence of specific intramolecular interactions, residual silanol groups of reversed-phase sorbents should not affect the linearity of plots in the coordinates used in the method of relative retention analysis for pairs of substances. The validity of the method proposed previously for analysis of the selectivity of separation of substances was supported experimentally (based on the analysis of retention of substituted benzoates). The possibility of the extension of incremental relationships to the system consisting of three different substances was justified.