Catalytic asymmetric Pictet-Spengler reaction |
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| Authors: | Seayad Jayasree Seayad Abdul Majeed List Benjamin |
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| Affiliation: | Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany. |
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| Abstract: | A catalytic asymmetric Pictet-Spengler reaction has been developed, wherein treating substituted tryptamines with an aldehyde in the presence of a catalytic amount of a chiral phosphoric acid provides the corresponding tetrahydro-beta-carboline derivatives in high yields and enantiomeric excesses. The reaction works well with both aliphatic and aromatic aldehydes. |
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