Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives |
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Authors: | Aitor Maestro Xabier del Corte Adrin Lpez-Francs Edorta Martínez de Marigorta Francisco Palacios Javier Vicario |
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Institution: | 1.Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados “Lucio Lascaray”-Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain; (A.M.); (X.d.C.); (A.L.-F.); (E.M.d.M.);2.Stratingh Institute for Chemistry, University of Groningen, 9747 AG Groningen, The Netherlands |
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Abstract: | Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the biological activity of chiral molecules into their absolute configuration, the synthesis of α-aminophosphonates bearing tetrasubstituted carbons in an asymmetric fashion has grown in interest in the past few decades. In the following lines, the existing literatures for the synthesis of optically active tetrasubstituted α-aminophosphonates are summarized, comprising diastereoselective and enantioselective approaches. |
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Keywords: | asymmetric synthesis α -aminophosphonic acid tetrasubstituted carbons diastereoselective enantioselective α -aminophosphonates |
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