Densazalin,a New Cytotoxic Diazatricyclic Alkaloid from the Marine Sponge Haliclona densaspicula |
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Authors: | Buyng Su Hwang Yong Tae Jeong Sangbum Lee Eun Ju Jeong Jung-Rae Rho |
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Affiliation: | 1.Department of Oceanography, Kunsan National University, Jeonbuk 54150, Korea; (B.S.H.); (S.L.);2.Nakdonggang National Institute of Biological Resources, Gyeongbuk 37242, Korea;3.Department of Plant & Biomaterials Science, Gyeongsang National University, Jinju 52725, Korea |
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Abstract: | Densazalin, a polycyclic alkaloid, was isolated from the marine sponge Haliclona densaspicula collected in Korea. The complete structure of the compound was determined by spectroscopic methods, including 1D and 2D nuclear magnetic resonance techniques, high-resolution mass spectrometry, and comparison of the calculated and measured electronic circular dichroism spectra. Densazalin possesses a unique 5,11-diazatricyclo[7.3.1.02,7]tridecan-2,4,6-triene moiety, which is connected by two linear carbon chains. This compound was derived from the biogenetic precursor bis-1,3-dialkylpyridnium. Densazalin exhibited cytotoxic activity on two human tumor cell lines (AGS and HepG2) in the Cell Counting Kit-8 (CCK-8) bioassay, with IC50 values ranging from 15.5 to 18.4 μM. |
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Keywords: | Haliclona densaspicula densazalin 1 3-alkylpyridine cytotoxic alkaloid |
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