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Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory,Pain Relief and Antibiotics-Type Mechanisms
Authors:Rocco Giordano  Zeinab Saii  Malthe Fredsgaard  Laura Sini Sofia Hulkko  Thomas Bouet Guldbk Poulsen  Mikkel Eggert Thomsen  Nanna Henneberg  Silvana Maria Zucolotto  Lars Arendt-Nielsen  Jutta Papenbrock  Mette Hedegaard Thomsen  Allan Stensballe
Abstract:The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species Aster tripolium, Crithmum maritimum and Salicornia europaea, are summarized and discussed. All three of them have been widely used in natural folk medicines and are now in the focus for future nutraceutical and pharmacological applications.
Keywords:secondary metabolites  halophytes  hydroxycinnamic acid  inflammation  nutraceuticals
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