Antitumor Activity and Potential Mechanism of Novel Fullerene Derivative Nanoparticles |
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| Authors: | Lianjie Ye Larwubah Kollie Xing Liu Wei Guo Xiangxian Ying Jun Zhu Shengjie Yang Meilan Yu |
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| Affiliation: | 1.College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China; (L.Y.); (L.K.); (X.L.); (W.G.);2.Shaoxing Academy of Biomedicine, Zhejiang Sci-Tech University, Shaoxing 312030, China;3.College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China;4.Hangzhou Wahaha Co., Ltd., Hangzhou 310018, China; |
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| Abstract: | The development of novel nanoparticles as a new generation therapeutic drug platform is an active field of chemistry and cancer research. In recent years, fullerene nanoparticles have received extensive attention due to their unique physical and chemical properties. Properly modified fullerene nanoparticles have excellent biocompatibility and significant anti-tumor activity, which makes them have broad application prospects in the field of cancer therapy. Therefore, understanding the anti-tumor mechanism of fullerene nanoparticles is of great significance for the design and development of anti-tumor drugs with low toxicity and high targeting. This review has focused on various anti-tumor mechanisms of fullerene derivatives and discusses their toxicity and their distribution in organisms. Finally, the review points out some urgent problems that need solution before fullerene derivatives as a new generation of anti-tumor nano-drug platform enter clinical research. |
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| Keywords: | fullerene anti-tumor cancer nanoparticle nanomedicine |
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