Sequence dependence of methylation rate enhancement in meta-phenyleneethynylene foldamers |
| |
| Authors: | Smaldone Ronald A Moore Jeffrey S |
| |
| Affiliation: | Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA. |
| |
| Abstract: | The methylation rates of a meta-phenyleneethynylene (mPE) oligomer with a terminally-attached 4-dimethylaminopyridine (DMAP) residue are reported for a series of linear and branched methyl sulfonates; these data show that selective methylation is enhanced by locating the DMAP unit at the midpoint of the sequence, allowing the foldamer cavity to function as a reactive sieve. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
