| 铱催化 3-羟甲基-2H-苯并吡喃类化合物的不对称氢化 |
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| 引用本文： | 刘启宾,周永贵.铱催化 3-羟甲基-2H-苯并吡喃类化合物的不对称氢化[J].催化学报,2007,28(10):847-849. |
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| 作者姓名： | 刘启宾 周永贵 |
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| 作者单位： | 中国科学院大连化学物理研究所,辽宁大连,116023 |
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| 基金项目： | 国家自然科学基金(20672112) |
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| 摘 要： | 从(1R,2S)-环己烷吡啶醇出发,合成了具有不同轴手性的反式环己烷骨架铱络合物,并将其应用于3-羟甲基-2H-苯并吡喃的不对称氢化中.结果表明,当以Ir-8为催化剂,二氯甲烷为溶剂,氢气压力5MPa,室温反应16h时,可以取得极好的反应活性,产物最高对映选择性可达94%.
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| 关 键 词： | 3-羟甲基-2H-苯并吡喃 不对称氢化 铱催化剂 |
| 文章编号： | 0253-9837（2007）10-0847-03 |
| 修稿时间： | 2007-06-19 |
Iridium-Catalyzed Asymmetric Hydrogenation of (2H-chromen-3-yl)methanols |
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| LIU Qibin,ZHOU Yonggui.Iridium-Catalyzed Asymmetric Hydrogenation of (2H-chromen-3-yl)methanols[J].Chinese Journal of Catalysis,2007,28(10):847-849. |
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| Authors: | LIU Qibin ZHOU Yonggui |
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| Institution: | Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, Liaoning , China |
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| Abstract: | Trans-cyclohexane-backbone iridium complexes with different axial chirality were synthesized from(1R,2S)-2-(pyridin-2-yl)cyclohexanol,and their application in asymmetric hydrogenation of(2H-chromen-3-yl)methanols was investigated.When the hydrogenation was carried out using 1% Ir-8 as the catalyst at a hydrogen pressure of 5 MPa in dichloromethane for 16 h at room temperature,excellent activities and up to 94% ee were obtained. |
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| Keywords: | (2H-chromen-3-yl)methanol asymmetric hydrogenation iridium catalyst |
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