Synthese und Konfigurationszuordnung eines potentiell antimikrobiellen 5,6-Dihydroxyisobenzofuranons

Summary Isobenzofuranone3 was prepared by KMnO₄-oxidation of2. 3 was reacted to give acetals4–10, which adopt the boat-conformation.3 and its acylated derivatives11–13 on the other hand prefer the chair-conformation. The relative configurations of3–13 at the chiral centres 3a, 5, 6, and 7a were determined by¹H-NMR-spectroscopy.