A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships |
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| Authors: | Nasveschuk Christopher G Ungermannova Dana Liu Xuedong Phillips Andrew J |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309-0215, USA. |
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| Abstract: | A total synthesis of largazole that proceeds in 8 steps from commercial materials is reported, along with some structure-activity relationships. A combination of NMR studies and molecular modeling have also provided a preliminary picture of the conformation of largazole. |
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