The application of capillary SFC,packed column SFC,and capillary SFC-MS in the analysis of controlled drugs

Multi–component mixtures of controlled drugs, drug impurities, and adulterants have been analyzed by capillary SFC-FID, packed column SFC-UV, and capillary SFC-MS. Isocratic packed column SFC has been performed with binary and ternary mobile phases using a single syringe pump. The combination of capillary SFC and double focusing MS is described with reference to MS source pressures and the spectra obtained. The use of negative temperature programming in SFC is described.