Hydrolysis of 3,4-diphenyl-1,2,5-thiadiazole-1,1-dioxide. Acid and base catalysis |
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Authors: | M V Mirifico E J Vasini J E Sicre |
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Abstract: | We have performed a product and kinetic study of the hydrolysis of 3,4-diphenyl-1,2,5-thiadiazole-1,1-dioxide in aqueous solution. Benzil and sulfamide are the only products of hydrolysis and are formed in equimolar yields. The kinetic results indicate that a first order law is followed up to 90% conversion. The observed rate constant is independent of substrate concentration. Ionic strength and buffer concentration do not affect the rate constant, but the reaction is acid-base catalyzed. The rate-pH profile has been determined and a mechanism that fits the experimental data satisfactorily is proposed. Corresponding rate constants and equilibrium constants for the protonation of the substrate are reported. |
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