Nouvelle méthode d'accès aux benzo[h]furo[3,2-c]quinoléines,analogues isostériques des benzo[c]phénanthridines |
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Authors: | O Duval L Mavoungou Goms |
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Institution: | O. Duval,L. Mavoungou Gomès |
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Abstract: | A convenient synthesis of the benzoh]furo3,2-c]quinoline ring is reported. Hydrogenation of dienic adducts 5 gives comppounds 6. Successive pyrolysis and alcaline hydrolysis of 6 provide diacids 9 which in the presence of anhydrous ammonium acetate and acetic acid undergoes intramolecular cyclisation to give benzoh]furo3,2-c]quinolone derivatives 12. The modulation of the 7-carboxy group and introduction of amino groups in the 6 position are then realized. |
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