Abstract: | A computer-assisted retention prediction system (RPS) of fifteen O-ethyl O-aryl N-isopropyl phosphoramidothioates ( 1 ) in reversed-phase HPLC was investigated. The system is based on the use of four physicochemical parameters (hydrophobicity II, electric effect σ, field effect F and steric effect Es) which is closely related to the retention mechanism in reversed-phase HPLC. The system was evaluated by comparing the measured retention data with the predicted ones. The predicted values were consistent with the measured values within a relative error of 11.5%. |