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Biosynthesis of the Spermine Alkaloid Aphelandrine |
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| Authors: | Georgios Papazoglou Jorge Sierra Katharina Homberger Armin Guggisberg Wolf-Dietrich Woggon Manfred Hesse |
| Abstract: | Aphelandrine ( 1 ) is shown to be biosynthesized in the root cells of Aphelandra tetragona (VAHL ) NEES from labelled putrescine ( 4 ), spermidine ( 5 ), and cinnamic acid ( 3 ). Whether spermine ( 6 ) and the (p-hydroxycinnamoyl)spermidine 8 are precursors of 1 is uncertain, since the latter is hydrolysed to a large extent before incorporation, and the former is metabolized to 4 and 5 . Methionine ( 7 ) is the source of the 3-aminopropyl unit of 5 and 6 . |
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